A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy

Inclusion Criteria: * Subjects must have histologically confirmed diagnosis of a non-small cell lung cancer, breast cancer, melanoma or renal cell cancer primary * Subjects must have \>5 contrast-enhancing lesions, never previously treated with SRS and/or surgical resection, on a contrast-enhanced T1-weighted brain MRI performed within two weeks of enrollment, with at least one lesion \>0.5cm in greatest dimension * Physical examination by a radiation oncologist or medical oncologist within 14 days of the start of WBRT * Plan to be treated with WBRT to a dose of 30 Gy in 10 fractions * Age \* 18 years * Karnofsky Performance Status (KPS) ≥ 70 * Hemoglobin ≥ 9.0 g/dl, ANC ≥ 1,500 cells/\*l, platelets ≥ 125,000 cells/\*l * Serum creatinine ≤ 1.5 mg/dl, serum SGOT and bilirubin ≤ 1.5 times upper limit of normal * Signed informed consent approved by the Institutional Review Board * If sexually active, patients must agree to use appropriate contraceptive measures for the duration of the study and for 6 months afterwards as stated in the informed consent * Able to provide study specific informed consent * Willing to follow study procedures, complete QOL questionnaires and neurocognitive testing as described in the protocol * Negative serum pregnancy test for women of child bearing potential within 48 hours of first dose of BMX Exclusion Criteria: * Active infection requiring IV antibiotics 7 days before enrollment * Hypertension requiring 3 or more anti-hypertensive medications to control * Requirement for concurrent treatment with nitrates or other drugs that may, in the judgment of the treating investigator, create a risk for a precipitous decrease in blood pressure * History of syncope within the last 6 months * Subjects receiving prohibited medications listed in Section 6.4.2 of this protocol are not eligible. Subjects who can safely stop taking a prohibited medication at least 7 days prior to the first dose of BMX may participate at the discretion of the treating physician. * Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic * Women who are breast feeding * Known hypersensitivity to compounds of similar chemical composition to BMX-001 * Prior surgical resection for brain metastases and/or stereotactic radiosurgery for up to 5 brain metastases in total are permitted if performed at least 1 month prior to planned WBRT under this protocol. * Prior whole brain radiation therapy * Patients with diffuse leptomeningeal disease (carcinomatous meningitis) * A marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval \>480 milliseconds (ms) (CTCAE grade 1) * A history of additional risk factors for TdP (e.g., congestive heart failure, hypokalemia, known family history of Long QT Syndrome)