Based on the hypothesis that high-frequency repetitive transcranial magnetic stimulation(rTMS) on the right dorsolateral prefrontal cortex(DLPFC) and left parietal cortex(LPC) could normalise cognitive abnormalities by promoting hippocampal neurogenesis and cortical-hippocampal function in patients with schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of intermittent theta burst stimulation (iTBS) on cognitive impairment in SZ patients with memory defects,as well as to elucidate the correlation between treatment effects and hippocampal neuroplasticity.
This study includes 150 schizophrenia patients and 30 healthy controls.This study will investigate 1).abnormalities of hippocampal neurogenesis in patients with schizophrenia compared to healthy controls by using 1H-MRS technique 2a).potential modulation effects of repetitive transcranial magnetic stimulation(rTMS) on hippocampal neurogenesis and cortical-hippocampal function of patients with schizophrenia 2b).the optimal rTMS therapy pattern on promoting hippocampal neurogenesis and improving cortico-hippocampal function by comparing the outcome of stimulating two regions(right dorsolateral prefrontal cortex or left parietal cortex) respectively 3).the therapeutic efficacy of rTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluation,as well as to explore the optimal rTMS treatment pattern on cognitive function by comparing the outcome of stimulating two regions(DLPFC or LPC) respectively 4)association between therapeutic efficacy of rTMS on cognitive deficits and rTMS modulation on hippocampal neurogenesis and its network function,in order to elucidate the underlying mechanism of therapeutic effects of rTMS on cognitive dysfunction in schizophrenia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
180
high frequency(20Hz) repetitive transcranial magnetic stimulation on dorsolateral prefrontal cortex(DLPFC) .Duration:10 days.
high frequency(20Hz) repetitive transcranial magnetic stimulation on left parietal cortex(LPC).Duration:10 days
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Change from baseline in MATRICS Consensus Cognitive Battery
MATRICS Consensus Cognitive Battery
Time frame: baseline,24 hours after the rTMS treatment,30 days
Change of hippocampal neurogenesis(from baseline)
Quantify neural stem cells in hippocampal by using H1-MRS
Time frame: baseline,24 hours after the rTMS treatment
Change of cortical-hippocampal functional network(from baseline)
Resting-state fMRI data are acquired
Time frame: baseline,24 hours after the rTMS treatment
Change from baseline in associative memory
associative memory
Time frame: baseline,24 hours after the rTMS treatment,30 days
Change from baseline in Positive and Negative Syndrome Scale(PANSS)
Positive and Negative Syndrome Scale(PANSS)
Time frame: baseline,24 hours after the rTMS treatment,30 days
Change from baseline in the Scale for the Assessment of Negative Symptoms(SANS)
Scale for the Assessment of Negative Symptoms
Time frame: baseline,24 hours after the rTMS treatment,30 days
Change from baseline in UCSD Performance-based Skills Assessment-Brief(UPSA-B)
UCSD Performance-based Skills Assessment-Brief
Time frame: baseline,24 hours after the rTMS treatment,30 days
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