PRediction of Acute Coronary Syndrome in Acute Ischemic StrokE

Charite University, Berlin, Germany254 enrolled

Overview

The primary goal of the PRAISE study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients with elevated levels of cardiac troponin.

Elevation of cardiac troponin can be found in about 30% of patients with acute ischemic stroke (depending on the assay used). Elevated troponin indicates increased mortality in stroke patients. There is currently little evidence regarding the ideal care of these patients. The investigators know from previous studies that approximately 25% of acute stroke patients with elevated levels of cardiac troponin have culprit lesions on coronary angiogram. The primary goal of the PRAISE study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients. To achieve this, clinical symptoms, troponin levels as well as findings on EKG, echocardiography and coronary angiography will be systematically evaluated. The PRAISE study is a multicenter study with more than 20 sites in Germany. Joint funding will be provided by DZHK (German center of cardiovascular research) und DZNE (German center of neurodegenerative diseases). Acute ischaemic stroke patients with elevated troponin are eligible for participation in the study. The primary endpoint is the diagnosis of acute coronary syndrome as established by an independent endpoint committee.

Study Type

OBSERVATIONAL

Enrollment

254

Conditions

Stroke, Ischemic Acute Coronary Syndrome

Interventions

Coronary angiographyDIAGNOSTIC_TEST

In patients eligible for participation in the study coronary angiography, echocardiography and EKG will be performed systematically.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of ischemic stroke based on clinical and imaging information (CT or MRI) * diagnosis of transient ischemic attack if the initial focal neurological deficit has been examined by a neurologist and if the ABCD2-score is ≥ 4 * Elevation of high-sensitive cardiac troponins according to the rule-in/rule-out algorithm of the 2015 ESC guidelines for NSTE-ACS, i.e. highly abnormal troponin at 0 hours (\> 52ng/l if hs-cTnT, Elecsys-Assay, or \> 52ng/l, if hs-cTnI; Architect-Assay, or \> 107 ng/l, if hs-cTnI. Dimension Vista Assay) or dynamic change \> 20% of the initial value at re-test after 3 hours with at least one value above the 99th percentile of a healthy reference population * ability to give informed consent * onset of symptoms \< 72 hours prior to hospital admission Exclusion Criteria: * renal insufficiency (GFR \< 30 ml/min/m²) * contraindications for coronary angiography (e.g. manifest hyperthyroidism, allergy to contrast agent) * lesion size \> 100 ml (either on Diffusion Weighted Imaging on cMRI or on CT if CT is performed \> 24 hours after onset) or ASPECTS score \< 7 (on CT if CT is performed \< 24 hours after onset) * Premorbid degree of dependence (mRS \> 3) * pregnancy or breast-feeding * limited life expectancy \< 1 year * consent to participate in the study given \> 72 hours after hospital admission

Locations (28)

Rhön-Klinikum Campus Bad Neustadt

Bad Neustadt an der Saale, Germany

Outcomes

Primary Outcomes

Presence of Myocardial Infarction

the diagnosis will be established by an independent endpoint committee

Time frame: within seven days of admission to hospital

Secondary Outcomes

Mortality

mortality will be recorded during the stay in hospital as well as after three and twelve months

Time frame: at one week and at three and twelve months after the initial event, at 12 months reported.

Functional Outcome

functional outcome will be evaluated using the modified Rankin scale (0-6 with greater scores indicating poorer functional outcome)

Time frame: at baseline, at one week and at three and twelve months after the initial event, 12 months reported

Cardiovascular Events

cardiovascular events include new stroke, transient ischemic attack and myocardial infarction and mortality

Time frame: at one week and at three and twelve months after the initial event, 12 months reported

Data from ClinicalTrials.gov

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