The investigators are performing this research study to find out if intravenous (IV) methylphenidate (commonly known as Ritalin) can help people recover faster from propofol sedation. The investigators also want to know how IV methylphenidate acts in the brain and whether IV methylphenidate is safe to take with an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness) without causing too many side effects. The brain's electrical activity will be studied and recorded using a machine called an electroencephalogram (EEG).
During this research study, participants will receive propofol, and propofol and IV methylphenidate together, at a high enough dose to achieve unconsciousness (make study participants "fall asleep"). During one visit participants will receive propofol and a saline placebo; during another visit participants will be given both propofol and IV methylphenidate together. The investigators will record EEG the entire time, The investigators will also ask some questions related to cognitive function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Subjects will receive a bolus of IV methylphenidate during propofol infusion at one of the study visits.
Subjects will received propofol for up to 100 minutes.
Massachusetts General Hospital
Boston, Massachusetts, United States
Change in multitaper spectral estimates of EEG power during a continuous infusion of propofol.
Change from baseline in multitaper spectral estimates of EEG power associated with the administration of IV methylphenidate.
Time frame: Up to 100 minutes
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