Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles

Inclusion Criteria: * Pregnant patients ≥ 18 years of age * Singleton pregnancy * Gestational age 6 weeks and 0 days through gestational age 13 weeks and 6 days Exclusion Criteria: * Pregnant patients \<18 years of age * Multiple gestations * Gestational age less than or equal to 5 weeks and 6 days * Gestational age greater than or equal to 14 weeks and 0 days * Institutionalization for psychiatric disorder, mental retardation, or criminal activity * Inability to provide informed consent * Major medical complication of pregnancy, including but not limited to: Diabetes, Chronic hypertension, Severe obesity with body mass index greater than or equal to 40 kg/m2 * Major surgical complications of pregnancy, including but not limited to: History of Bariatric surgery * Major obstetrical complication of pregnancy, including but not limited to: History of spontaneous preterm birth * Known maternal or fetal chromosomal abnormality * Major fetal anomaly * Intrauterine fetal demise * Human immunodeficiency virus (HIV) or Hepatitis * Chronic immunosuppressive medications or steroids * Current use of probiotic supplementation * Active urinary or vaginal infection * Current use of antibiotics * Current use of vaginal medication (e.g. vaginal progesterone) * Cerclage in place