Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes on people over 65 years. According to studies, 30 to 40% of isolated atrial fibrillations could be familial. Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been identified as potentially involved. Studies have identified genes common to the risk of atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has been intensively and extensively studied for almost a century, there are still many questions. The pathophysiology is not sufficiently understood to allow finding more effective therapies. It is necessary to identify genetic determinants and thus potentially new pharmacological targets more adapted. The establishment of a biological database will test hypotheses concerning the genetic origin and thromboembolic process of atrial fibrillation and associated stroke.
Study Type
OBSERVATIONAL
Enrollment
1,000
Collection of clinical data
Collection of DNA
Collection of plasma
Service neurologie Centre hospitalier Fleyriat
Bourg-en-Bresse, France
RECRUITINGService d'urgences Neurovasculaires - service de neurologie vasculaire , Hôpital Pierre Wertheimer
Bron, France
RECRUITINGService de rythmologie, hôpital cardiologique Louis Pradel
Bron, France
RECRUITINGService de médecine gériatrique Centre hospitalier Lyon Sud, Groupement hospitalier Sud
Pierre-Bénite, France
RECRUITINGHôpital des charpennes
Villeurbanne, France
RECRUITINGQuality of DNA sample
Quality is based on the measure of the purity of DNA with absorbance assay at 260/280nm on a spectrophotometer. For Plasma sample, purity is based on absence of hemolyzed blood by visual observation.
Time frame: 1 day (the day of the storage)
Quality of Plasma sample
Quality is based on the purity of Plasma sample that is based on absence of hemolyzed blood by visual observation.
Time frame: 1 day (the day of the storage)
Quality of preservation of the sample
The quality of preservation of the sample throughout the conservation duration is based on the number of freezing/thawing of each cryotube that will be notified. As weel as any interruption in the freezing process (power failure, freezer failure).
Time frame: 7 years (during all the duration of the collection)
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