Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Teeth

N/ACompletedNCT03611920

University of Bern33 enrolled

Overview

To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.

Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined. Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dental Trauma Avulsion Periodontal Regeneration Pulpal Regeneration Topical Dexamethasone Topical Tetracycline

Interventions

TetracyclinePROCEDURE

Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation

DexamethasonePROCEDURE

Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation

Eligibility

Sex: ALLMin age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Avulsion of a permanent tooth * Written informed consent Exclusion Criteria: * Extended dry period of more than 60 minutes

Locations (1)

zmk Bern

Bern, Switzerland

Outcomes

Primary Outcomes

Number of teeth with periodontal regeneration

Periodontal regeneration was assessed with periodontal examination, percussion, Periotest measurements and periapical radiograph.

Time frame: After a mean observation period of 12.9±2.4 years (one visit only)

Number of teeth with pulpal regeneration

Pulpal regeneration was assessed with periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow and periapical radiograph.

Time frame: After a mean observation period of 12.9±2.4 years (one visit only)

Secondary Outcomes

Number of teeth that survived

Assessed by visual inspection

Time frame: After a mean observation period of 12.9±2.4 years (one visit only)

Number of teeth with open versus closed apex at accident

Assessed by x-ray

Time frame: At baseline

Patients satisfaction

Measured by OHIP-14 score

Time frame: After a mean observation period of 12.9±2.4 years (one visit only)

Data from ClinicalTrials.gov

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