Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Nanjing PLA General Hospital113 enrolled

Overview

Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

Study Type

OBSERVATIONAL

Enrollment

113

Conditions

Critical Illness Enteral Nutrition Inflammation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission * age more than 18 years * Acute Physiology and Chronic Health Evaluation II (APACHE II) score \>8 Exclusion Criteria: * not expected to survive 24 hours * pregnancy * any terminal stage disease

Outcomes

Primary Outcomes

28-day mortality

The number of survival and non-survival patients 28 days after inclusion

Time frame: 14 months

Intestinal barrier function within one week

The measurement of serum d-lactate was applied to evaluate the intestinal barrier function

Time frame: 14 months

Data from ClinicalTrials.gov

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