Influence of Medication on Functional Connectivity

Inclusion Criteria: 1. males or females, ages 18-30 2. for women of a child-bearing age, acceptable birth control methods or a negative pregnancy test prior to MRI scanning 3. ability to provide written, informed consent 4. eligibility and willingness to participate in fMRI scanning and to receive oxycodone 5. normal weight, as indicated by a body mass index (BMI) between 18.5 to 25 Exclusion Criteria: 1. current DSM-5 Axis I disorder 2. any psychotropic medication or medication known to interfere with metabolism of opioids 3. medical contraindication to participate in study activities (acute low-dose opioid admin) as determined by study physician 4. known family history (first-degree relative) of opioid-use disorder or alcohol-use disorder 5. not eligible for MRI scanning 6. positive drug screen 7. recent (past 6 months) medical or non-medical opioid-use 8. current or previous chronic pain disorder 9. significant lifetime use of prescription opioids (\>7 days of consecutive medical use or nonmedical use on more than 5 occasions)