A Research Study to Characterize the Pharmacodynamics and Safety of Repeat Dose SP-102

Main Inclusion Criteria: * Able and willing to read, write, and understand the English language and provide English language written informed consent prior to beginning any study procedures. * Age 18 to 70 years (inclusive) at the Screening Visit. * A diagnosis of lumbosacral radicular pain (sciatica). * Agrees to follow study-specific medication requirements. * If sexually active and a female of child-bearing potential or a male capable of bearing a child, agrees to use an effective method of birth control during the study. * Has reviewed all study specific materials and has, in the opinion of the Investigator, the abilities to understand and appropriately complete all study procedures. Main Exclusion Criteria: * Has radiologic evidence of a condition that would compromise study outcomes. * Has ever had lumbosacral back surgery or plans to undergo spine surgical intervention while in the study. * Has been diagnosed with insulin dependent diabetes mellitus. * Presence of any other disorder, condition or circumstance (including secondary gain) that, in the opinion of the Investigator, has the potential to prevent study completion and/or to have a confounding effect on outcome assessments. * Use of any investigational drug and/or device within 30 days, or is scheduled to receive an investigational drug other than blinded study drug during this study. * Has a body mass index ≥40 kg/m2.