Sugar-sweetened beverages are the main source of added sugars in most Westernized countries, and for this reason constitute a primary target for sugar reduction by many companies, including Nestlé. Instead of using high-intensity sweeteners which are non-caloric in nature, an alternative would be to reduce sugars without altering sweetness. In this protocol, the general goal is to investigate the relative contribution of sweet taste perception and sugar intake on post-prandial glucose response. 4 different nutritional products will be tested by 16 healthy subjects in a crossover design.
After enrollment, participants will be asked to come to the investigational site 6 times for: * two sensory tests dedicated to assess the sensory capacity of the participants from the same sensory test repeated twice, for better consistency. * 4 testing visits for a 3-h blood kinetics after each product intake. These visits will be scheduled on different days separated by a washout period of at least one week. Outcomes will be glycemia and insulinemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
16
Comparison with products 2, 3, and 4
Comparison with products 1, 3, and 4
Comparison with products 1, 2, and 4
Comparison with products 1, 2, and 3
Nestlé Research Center
Lausanne, Switzerland
Incremental Area under the Curve (iAUC) of plasma glucose
Area under the curve
Time frame: 0 to 3 hours post product intake
Incremental Area under the Curve (iAUC) of plasma insulin
Area under the curve
Time frame: 0 to 3 hours post product intake
Cmax of plasma glucose
Maximal concentration of plasma glucose
Time frame: between 0 and 3 hours post product intake
Cmax of plasma insulin
Maximal concentration of plasma insulin
Time frame: between 0 and 3 hours post product intake
Tmax of plasma glucose
Time (min) for maximal concentration of plasma glucose
Time frame: between 0 and 3 hours post product intake
Tmax of plasma insulin
Time (min) for maximal concentration of plasma insulin
Time frame: between 0 and 3 hours post product intake
Sensory tasting capacity
Assessment of the sweetness of two beverages versus control through a questionnaire
Time frame: immediately after product intake
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