A study designed to compare evening versus morning levothyroxine intake in the elderly.
This is a randomized crossover trial of two dosing strategies for pharmacological treatment of hypothyroidism in a sample of individuals aged 60 years or older, performed at an outpatient healthcare in a tertiary center.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
208
Bedtime levothyroxine intake, with 60-minute meal-free interval
Morning levothyroxine intake, 60 minutes before breakfast.
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
RECRUITINGVariation in TSH (Thyroid-Stimulating Hormone) levels.
Variation in TSH (Thyroid-Stimulating Hormone) levels after 24 weeks of levothyroxine use in the evening compared to the morning period.
Time frame: 24 weeks.
Prevalence of drugs with potential drug interaction with levothyroxine.
To identify the major medications that interfere with the absorption of levothyroxine.
Time frame: 24 weeks
Level of TSH (Thyroid-Stimulating Hormone) control in each group.
To compare the TSH (Thyroid-Stimulating Hormone) control efficacy between the two treatment strategies in this subgroup of participants.
Time frame: 24 weeks
TSH (Thyroid-Stimulating Hormone) levels of the patients at baseline
To assess the TSH (Thyroid-Stimulating Hormone) levels in this sample of patients at the time of study inclusion, in order to evaluate their real life in terms of adherence and relation with polypharmacy.
Time frame: Baseline (0 weeks)
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