The Efficacy of Salvage BGD With autoSCT Consolidation in Advanced Classical HL Patients Not Responding to ABVD

Inclusion Criteria: * Histologically confirmed Classical Hodgkin's Lymphoma treated with ABVD regimen with PET scan/CT performed before, during and after treatment, and also one of the following: * positive result (Deauville 4 and 5) of early PET scan after 2 ABVD courses * disease progression or relapse after first-line ABVD treatment or ABVD and radiotherapy combination treatment * No contraindications for salvage chemotherapy and ASCT * At least one measurable malignancy * ECOG performance status ≤ 3 * Written signed and dated informed consent prior to any study procedures being performed Exclusion Criteria: * Non-Classical Hodgkin's Lymphoma * Other than ABVD first-line treatment, preceding patient's inclusion * Lack of PET scans performed in accordance with inclusin criteria during ABVD treatment * Transformation of Hodgkin's Lymphoma * Central Nervous System (CNS) Metastases * Contraindications for ASCT or lack of patient's consens for the procedure * Second malignancy - active or cured less than 5 years prior * Uncontrolled diabetes * Hepatic impairment (bilirubin concentration ≥ 1.5 x ULN, SGOT \> 5 x ULN), if non-realted to the lymphoma or Gilbert's syndrome * HIV infection * Active HBV or HCV infection. Subjects who have had Hepatitis B and are abHBC positive, need to undergo HBV DNA test using a Polymerase Chain Reaction (PCR) technique and be applied appropriate preventive treatment. * Pregnancy or lactation * Hypersensitivity to any of the drugs * Lack of written informed consent