A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris

Inclusion Criteria: * Male or female, aged 12-40 years old * Diagnosis of Grade II-III acne vulgaris with Pillsbury grading system * Provide written informed consent if the subject is aged 18 or older. Ages 12-17 should provide written assent and written informed consent from patient's parent or legal guardian. Exclusion Criteria: * Known hypersensitivity to adapalene, clindamycin hydrochloride, clindamycin phosphate, lincomycin or any ingredient of the study drug, or of allergic constitution * Secondary Acne, such as occupational acne and steroid acne * Has a dermatological condition of the face that could interfere with the clinical evaluations, such as sunburn, psoriasis, seborrheic dermatitis or eczema * History of Crohn's disease, ulcerative colitis or antibiotic-associated colitis * History of serious heart disease or hypertension * Serious liver or kidney disease, AST or ALT more than twice the upper limit of normal, or Cr above normal * Serious endocrine, hematologic or psychiatric disease * Known immunocompromised conditions, or require long-term steroids or immunosuppressants * Females who are pregnant, lactating, or not willing to use effective contraception * Drug or alcohol abuse * Used any topical acne treatment within 2 weeks * Used any systemic retinoid, antibiotic or other acne treatment * Used any investigational drugs or device within 3 months, or concurrently enrolled in another clinical trial * Patient who the investigator deemed to be unsuitable for any reason