The Mechanism and Prognosis of Pulmonary Circulation Dysfunction

Chinese Academy of Medical Sciences, Fuwai Hospital1,000 enrolled

Overview

Venous thromboembolism (VTE) is a condition which influenced by both environmental and genetic factors. This study is going to explore new significant Single nucleotide polymorphisms (SNPs) associated with VTE by Genome-Wide Association Studies (GWAS) and bioinformatics analysis. Transcriptomics and cytokine antibody array are also used to find new biomarkers of VTE's early diagnosis, severity and prognosis.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

VTE

Eligibility

Sex: ALLMin age: 14 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese Han population older than 14 years old * Acute VTE patients diagnosed in 1 month * With informed consent Exclusion Criteria: * Patients with psychosis * Patients with contraindications for computed tomographic pulmonary angiography (CTPA) * Chronic VTE * Recurrence of chronic VTE

Locations (1)

Cardiovascular Institute and Fu Wai Hospital

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

All cause death

death

Time frame: 6 months

Secondary Outcomes

Venous thromboembolism (VTE) recurrence

VTE recurrence detected by echocardiography or CTPA scan

Time frame: 6months

chronic thromboembolism pulmonary hypertension(CTEPH)

newly developed CTEPH detected by pulmonary angiography

Time frame: 6 months

Central Contacts

Jianguo He, MD

CONTACT

80-10-88398060 hejianguofw@163.com

Data from ClinicalTrials.gov

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