Atezolizumab Monotherapy and Consequent Therapy With Atezolizumab Plus Bevacizumab for NSCLC

Inclusion Criteria: Patients must meet all of the following criteria to be eligible for study entry: 1. Signed Informed Consent Form 2. Ability to comply with protocol 3. 20 years old or older 4. Histologically confirmed stage IIIb, IV or recurrent non-squamous cell NSCLC 5. Baseline and repeat biopsy at the time of progression is mandatory. Repeat biopsy at progression to atezolizumab with bevacizumab is optional. 6. Disease progression during or following treatment with a prior platinum-containing regimen for locally advanced, unresectable/inoperable or metastatic NSCLC or disease recurrence within 6 months of treatment with a platinum-based adjuvant/neoadjuvant regimen or combined modality (e.g.,chemoradiation) regimen with curative intent. 7. ECOG performance status of 0 to 1 8. At least one measurable lesion by RECIST v1.1 9. Patients with brain metastasis may be enrolled provided they are asymptomatic requiring no treatment, or are asymptomatic following therapy such as surgery, WBRT or SRT. 10. Adequate hematologic and end organ function, defined by the following laboratory results obtained within 14 days prior to the first study treatment: Exclusion Criteria: Patients who meet any of the following criteria will be excluded from study entry. 1. Prior treatment with anti-PD1 or anti-PDL1 inhibitors 2. Patients with a known hypersensitivity to atezolizumab and/or bevacizumab or any of the excipients. 3. History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins. 4. Known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster ovary cells. 5. Patients with a sensitizing EGFR mutation 6. Patients with a previously detected ALK fusion oncogene 7. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment 8. Active autoimmune disease requiring systemic treatment within the past 3 months or a documented history of clinically severe autoimmune disease 9. Evidence of interstitial lung disease or active, non-infectious pneumonitis 10. Has received a live vaccine within 30 days prior to the first dose of trial treatment 11. Has a known history of Human Immunodeficieny Virus (HIV) 12. Has known active Hepatitis B (e.g. HBsAg reactive) or Hepatitis C (e.g. HCV RNA is detected) 13. Surgery undertaken less than 4 weeks before the study 14. Localized radiotherapy unless completed more than 2 weeks before the study 15. Uncontrolled systemic illness such as DM, CHF, unstable angina, hypertension or arrhythmia 16. Pregnant or breastfeeding or lactating female patients 17. Female participants of childbearing potential will not agree to use to highly effective form(s) of contraception (i.e., one that results in a low failure rate \[\<1% per year\] when used consistently and correctly) during the treatment period and to continue its use for 5 months after the last dose of Atezolizumab 18. Uncontrolled symptomatic brain metastasis 19. Prior history of malignancy within 5 years from study entry except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer, well-treated thyroid cancer 20. Inadequately controlled hypertension (defined as systolic blood pressure \>150 mmHg and/or diastolic blood pressure \>100 mmHg) Anti-hypertensive therapy to achieve these parameters is allowable. 21. Prior history of hypertensive crisis or hypertensive encephalopathy 22. Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis) within 6 months prior to randomization 23. History of hemoptysis (\>,=one-half teaspoon of bright red blood per episode) within 1 month prior to randomization 24. Evidence of bleeding diathesis or coagulopathy (in the absence of therapeutic anticoagulation) 25. Current or recent (within 10 days of Atezolizumab administration use of aspirin (\>325 mg/day) or treatment with dipyramidole, ticlopidine, clopidogrel, and cilostazol 26. Current use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic purposes that has not been stable for \>2 weeks prior to randomization 27. Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to the first dose of bevacizumab 28. History of abdominal or tracheosphageal fistula or gastrointestinal perforation within 6 months prior to randomization 29. Clinical signs of gastrointestinal obstruction or requirement for routine parenteral hydration, parenteral nutrition, or tube feeding 30. Evidence of abdominal free air not explained by paracentesis or recent surgical procedure 31. Serious, non-healing wound, active ulcer, or untreated bone fracture 32. Proteinuria, as demonstrated by urine dipstick or \>1.0 g of protein in a 24-hour urine collection All patients with \>, =2+ protein on dipstick urinalysis at baseline must undergo a 24 hour urine collection and must demonstrate \> 1 g of protein in 24 hours. 33. Clear tumor infiltration into the thoracic great vessels is seen on imaging 34. Clear cavitation of pulmonary lesions is seen on imaging