The main purpose of this study is to measure how much of the study drug gets into the bloodstream and how long it takes the body to get rid of it. This study will involve a single dose of 14C radiolabelled LY3154207. This means that a radioactive substance C14 will be incorporated into the study drug, to investigate the study drug and its breakdown products, to find out how much of these pass from blood into urine, feces and expired air. The study will last about 4 weeks. Screening is required within 28 days prior to the start of the study and follow up is required approximately 7 days after discharge.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
8
Administered orally
Administered orally
Covance Clinical Research Inc
Madison, Wisconsin, United States
Urinary Excretion of LY3154207 Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered
Urinary Excretion of LY3154207 Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered
Time frame: Baseline through 552 hours after administration of study drug
Fecal Excretion of LY3154207 Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered
Fecal Excretion of LY3154207 Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered
Time frame: Baseline through 552 hours after administration of study drug
Pharmacokinetics: Maximum Concentration (Cmax) of LY3154207
Pharmacokinetics: Cmax of LY3154207
Time frame: Predose through 144 hours after administration of study drug
Pharmacokinetics: Area Under the Concentration Time Curve From Time Zero to Infinity (AUC[0-∞])
Pharmacokinetics: AUC(0-∞)
Time frame: Predose through 144 hours after administration of study drug
Total Number of Metabolites
Total Number of Metabolites
Time frame: Baseline through 552 hours after administration of study drug
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