PROCLAIM -- Misoprostol in the Prevention of Recurrent CDI Prevent Recurrence of Clostridium Difficile Infection With Misoprostol

Inclusion Criteria 1. Episode of CDI, defined as ALL of the following: 1. ≥3 unformed (loose or watery) stools with a 24-hour period; 2. A documented positive C. difficile toxin assay (enzyme immunoassay \[EIA\] or cell cytotoxicity assay) or NAAT for toxigenic C. difficile from a stool sample collected while the subject was symptomatic; and 3. No other explanation for diarrhea (e.g. laxatives). 2. At the time of enrollment, on a course of oral antibiotics commonly used for treatment of CDI. 3. Be ≥18 years of age. 4. Be able to provide signed and dated informed consent. 5. Must be able to read and understand English. Exclusion Criteria 1. Have not recovered from primary episode of CDI at time of enrollment, defined as presence of EITHER of the following: 1. ≥3 unformed (loose or watery) stools during the 24 hours prior to randomization, OR 2. Abdominal discomfort (more than mild) present during the 24 hours prior to randomization. 2. Have received, or plans to use, any of the following for treatment of the primary episode of CDI: 1. Any immunotherapy (e.g., intravenous immunoglobulin, bezlotoxumab). 2. Any toxin-binding therapy (e.g., cholestyramine \[Questran\], colestipol \[Colestid\], or colesevelam \[Welchol\]). 3. Current or planned treatment with prostanoid therapy. 4. Diarrhea caused by another infection or diarrhea caused by an underlying gastrointestinal disorder. 5. Have any contraindication to oral/enteral therapy (e.g., severe nausa/vomiting or ileus). 6. Have an absolute neutrophil count \<500/mm3 \[1.0 x 109/L\] within 30 days of screening. 7. Require or have an anticipated need for mechanical ventilation or vasopressors for hemodynamic support during the study. 8. Pregnant, nursing, or planning to become pregnant. 9. Inability to understand the requirements of the study, inability to abide by the study restrictions. 10. Have any clinically significant medical or surgical condition that in the investigator's opinion could interfere with the administration of study drug, interpretation of study results, or compromise the safety or well-being of the subject. 11. Known hypersensitivity to misoprostol. 12. Be unwilling or unable to follow study procedures (e.g., study visits, swallow the study drug/placebo, provide stool samples and undergo phlebotomy according to the study schedule, and reliably report information by phone), or not have a caregiver who can ensure that study procedures are followed. 13. If female, be pre-menopausal (cessation of menses less than or equal to 1 year) and not surgically/medically sterile or not following acceptable non-hormonal method of birth control such as abstinence, intrauterine device, or barrier control for at least 1 complete menstrual cycle before the screening visit, or not using estrogen/progestin containing products for at least 2 months before the screening visit through discharge from the study. 14. Unreliable access to telephone service to allow for contact with study personnel. 15. Inability to be seen for routine clinical care either as an outpatient or inpatient.