Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder, which produces in 5-20% reproductive age women. In this study, a nontargeted metabolomics approach based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry will be used to investigate serum metabolic characteristics of PCOS. PCOS women and healthy control will be divided into two distinct groups based on multivariate statistical analysis. The findings of this study will offer a new insight to understand the pathogenesis mechanism, and the discriminating metabolites may provide a prospect for PCOS diagnosis.
Study Type
OBSERVATIONAL
Enrollment
1,272
First Affiliated Hospital, Heilongjiang University of Chinese Medicine
Harbin, Heilongjiang, China
The fatty acid amides (FAAs) metabolite changes
The metabolic changes between PCOS and healthy controls
Time frame: one year
The sulfated steroids metabolite changes
The metabolic changes between PCOS and healthy controls
Time frame: one year
The free fatty acid metabolite changes
The metabolic changes between PCOS and healthy controls
Time frame: one year
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