Anemia and Inflammation

Swiss Federal Institute of Technology50 enrolled

Overview

During inflammation hepcidin concentrations are increased, leading to a decrease in iron absorption. In iron deficiency anemia hepcidin is suppressed due to the activation of erythropoiesis. Whether inflammation or anemia has the stronger effect on hepcidin is uncertain.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Iron Deficiency Anemia Inflammation

Interventions

Dultavax and VaxigripBIOLOGICAL

All the women got an influenza/DTP vaccine in order to induce acute inflammation

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \<27.5kg/m2 * body weight \<70kg * either non-anemic (Hb\>12.5g/dl) or anemic (Hb between 8-12 g/dl and ferritin \<15ng/ml) Exclusion Criteria: * pregnant or lactating * chronic disease * smoking * inflammation defined as CRP\<5mg/L; AGP\<1g/L

Locations (1)

Ibn Tofail University-CNESTEN

Rabat, Morocco

Outcomes

Primary Outcomes

Fractional and total iron absorption

Time frame: 14 days after the second baseline test meal administration

Fractional and total iron absorption

Time frame: 14 days after the test meal administered 24 hours after vaccination

Secondary Outcomes

Serum hepcidin

Time frame: up to 36 hours

Serum Interleukin 6

inflammation

Time frame: up to 36 hours

Serum ferritin

Iron status

Time frame: up to 36 hours

Serum transferrin

Iron status

Time frame: up to 36 hours

Serum CRP

inflammation

Time frame: up to 36 hours

Serum AGP

inflammation

Time frame: up to 36 hours

Data from ClinicalTrials.gov

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