The purpose of this study was to compare the effects of liraglutide and testosterone replacement therapy on features of hypogonadism and weight loss in obese men with persistent features of hypogonadism after unsuccessful lifestyle measures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
In the liraglutide group liraglutide was initiated at a dose of 1.2 mg injected sc once per day and increased to 3 mg/day after 1 week.
In the testosterone group Androtop gel 5 grams (50 mg of testosterone) was applied once a day on a dry skin.
University Medical Center Ljubljana
Ljubljana, Slovenia
The main outcome was improvements of symptoms related to hypogonadism
Time frame: Patients were screened and asked for symptoms at the beginning and every 4 weeks for 16 weeks of the study.
The main outcome was change testosterone level.
Patient's blood was drawn between 8 and 9 a.m. Concentrations of testosterone was measured in nmol/L.
Time frame: Patient's blood was drawn at the base point and every four weeks during 16 weeks of clinical trial.
the main outcome was change in gonadotropin levels.
Time frame: Patient's blood was drawn at the base point and every four weeks during 16 weeks of clinical trial.
The secondary outcome was change in body weight.
Time frame: Patient's body weight in kilograms were measured at the base point and every four weeks during the 16 weeks of clinical trial.
The secondary outcome was change in waist circumference.
Patient's waist circumference was measured in centimeters.
Time frame: Patient's waist circumference was measured at the basepoint and every four weeks during 16 weeks of clinical trial.
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