The purpose of this study is to evaluate how effective is the intraoperative use of lidocaine to attenuate postoperative pain and opioids consumption after laparoscopic cholecystectomy
Acute postoperative pain may predict the development of chronic pain.Recently, the analgesic effect of lidocaine, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that lidocaine may have a role in the postoperative pain management, as an adjunct. Acute postoperative pain after laparoscopic cholecystectomy is complex in nature. Postoperative pain is the main complaint and the primary reason for delay discharge after laparoscopic cholecystectomy.The study includes patients undergoing laparoscopic cholecystectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
98
University Hospital of Larissa
Larissa, Greece
Postoperative opioid consumption
The total dose of tramadol is calculated as mg and administered intravenously.
Time frame: 24 hours after the procedure
Postoperative pain
Numeric Rate scale 0-10 (0=no pain to 10=worst imaginable pain)
Time frame: Departure of the patient from the recovery room (0hrs)
Postoperative pain
Numeric Rate scale 0-10 (0=no pain to 10=worst imaginable pain)
Time frame: 6 hrs after the procedure
Postoperative pain
Numeric Rate scale 0-10 (0=no pain to 10=worst imaginable pain)
Time frame: 12 hrs after the procedure
Postoperative pain
Numeric Rate scale 0-10 (0=no pain to 10=worst imaginable pain)
Time frame: 24 hrs after the procedure
Incidence of Nausea and Vomiting
The percentage of patients who had nausea and vomiting during the first 24 hours
Time frame: 24 hours
Incidence of sedation and respiratory depression
The percentage of patients who had sedation and respiratory depression during the first 24 hours
Time frame: 24 hours
Incidence of shoulder pain
The percentage of patients who had shoulder pain during the first24 hours
Time frame: 24 hours
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Incidence of headache and dizziness
The percentage of patients who had headache and dizziness during the first 24 hours
Time frame: 24 hours
Change from baseline Mean Blood Pressure
Non-invasive blood pressure measurement by using sphygmomanometer cuff
Time frame: Intraoperative
Change from Baseline Heart Rate
Bradycardia, tachycardia during the procedure
Time frame: Intraoperative
Change in depth of anesthesia
Maintenance of Bispectral index (BIS) values of 40 to 50
Time frame: Intraoperative
Side effect related to administration of lidocaine
The percentage of patients who had tremor, dizziness, dysarthria, agitation, hallucinations and drowsiness during the first 24 hours
Time frame: 24 hours