Behavioral Therapy for Children and Adolescents With Tourette Syndrome

Taipei Medical University46 enrolled

Overview

Tourette Syndrome (TS) is a common neuropsychiatric disorder in childhood and adolescence, and often comorbid with psychiatric comorbidity. Antipsychotic medications are usually the first choices, but may associate with adverse effects. Behavioral intervention for TS has been shown to be an effective treatment for children and adolescents, yet have not been performed and evaluated using control trails in Taiwan.

TS is a common neuropsychiatric disorder in childhood and adolescence, and often comorbid with psychiatric comorbidity. Antipsychotic medications are usually the first choices, but may associate with adverse effects. Behavioral intervention for TS has been shown to be an effective treatment for children and adolescents, yet have not been performed and evaluated using control trails in Taiwan. This study therefore was to evaluate the efficacy of a comprehensive behavioral intervention therapy on improving tics and tic-related impairment for children and adolescents with Tourette syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Tourette Syndrome

Interventions

habit reversal training (HRT)BEHAVIORAL

The intervention group received 4 sessions during 3months of behavior intervention and then, were reassessed at 3 and 6 months following treatment. Pyridoxine(50mg)

Eligibility

Sex: ALLMin age: 6 YearsMax age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * DSM-5 Diagnostic Criteria For Tourette Syndrome * Patients aged from 6-15 years who were diagnosed with TS or CTD, * Never received any pharmacological treatment * Ability to understand the study purpose and/or provide consent for participation independently and via a caregiver serving as a proxy Exclusion Criteria: * Have been diagnosed with another mental illness, * Had no physical or medical condition, * Had been received CBIT or cognitive behavior therapy before.

Outcomes

Primary Outcomes

Eefficacy of a behavioral therapy on improving tics with Tourette syndrome

Behavioral intervention group led to a significantly greater decrease in total motor score on the Yale Global Tic Severity Scale .The gold-standard measure of tic severity in TS, the YGTSS is a clinician-completed measure consisting of a tic symptom checklist, motor and vocal tic severity ratings, and a global tic impairment rating. To ascertain tic severity ratings, the examiner rates five different dimensions of tic severity each on a 0-5 scale: tic number, frequency, duration, intensity, and complexity. Each of the dimensions is scored separately for motor and vocal tics to produce motor and vocal tic subscale scores (range 0-25). These subscales are then combined to produce a total tic severity score (range 0-50), with higher numbers indicating more severe tics. The YGTSS has demonstrated acceptable internal consistency and acceptable convergent and divergent validity).

Time frame: at 3rd month and 6rd months following treatment.

Data from ClinicalTrials.gov

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