A Comparative Pharmacokinetic Study to Evaluate the Ability of a New Formulation to Enhance Curcuminoids Bioavailability

Inclusion Criteria: * Age between 18 and 45 years (limits included), * BMI between 19 and 25 kg/m² (limits included), * Weight stable within ±3kg in the last three months, * With routine blood chemistry values within the normal range * For women: Non menopausal with the same reliable contraception since at least 3 cycles before the beginning of the study and agreeing to keep it during the entire duration of the study (condom with spermicidal gel and estrogen/progestin combination contraception accepted) or menopausal without or with hormone replacement therapy (estrogenic replacement therapy begun from less than 3 months excluded), * Non smoking or with tobacco consumption ≤ 5 cigarettes / day and agreeing not to smoke during all experimental sessions (V1 to V5), * Agreeing not to consume food, drink and condiment containing curcumin, turmeric (curcuma longa Linn.) or curry for 1 week prior to and throughout the entire study, * Good general and mental health with in the opinion of the investigator: no clinically significant and relevant abnormalities of medical history or physical examination, * Able and willing to participate to the study by complying with the protocol procedures as evidenced by his dated and signed informed consent form, * Affiliated with a social security scheme, * Agreeing to be registered on the volunteers in biomedical research file Exclusion Criteria: * Suffering from a metabolic or endocrine disorder such as diabetes, uncontrolled or controlled thyroidal trouble or other metabolic disorder, * Suffering from a severe chronic disease (e.g. cancer, HIV, renal failure, ongoing hepatic or biliary disorders, chronic inflammatory digestive disease, arthritis or other chronic respiratory trouble, etc.) or gastrointestinal disorders found to be inconsistent with the conduct of the study by the investigator (e.g. celiac disease), * Suffering from liver diseases * Current disease states that are contraindicated to subjects with dietary supplementation: chronic diarrhea, constipation or abdominal pain, Inflammatory bowel diseases (Crohn's disease or ulcerative colitis), Cirrhosis, chronic laxatives use…, * Suffering from Irritable Bowel Syndrome (IBS) diagnosed by a medical doctor and treated with chronic medication, * Having medical history of current pathology which could affect the study results or expose the subject to an additional risk according to the investigator, * Recent gastroenteritis or food borne illness such as confirmed food poisoning (less than 1 month), * Who made a blood donation in the 3 months before the V0 visit or intending to make it within 3 months ahead, * With a low venous capital not allowing to perform kinetic of blood samples according to the investigator's opinion, * With a known or suspected food allergy or intolerance or hypersensitivity to any of the study products' ingredient and/or of the standard meals (gluten intolerance, celiac disease, etc….) * Pregnant or lactating women or intending to become pregnant within 3 months ahead, * Exhibiting alcohol or drug dependence * On any chronic drug treatment (for example anticoagulant, antihypertensive treatment, treatment thyroid, asthma treatment, anxiolytic, antidepressant, lipid-lowering treatment, corticosteroids, phlebotonic, veino-tonic, drug with impact on blood circulation …) excepting oral and local contraceptives, * Currently taking (and during the past 3 months) any supplementation from botanical origins * Having consumed curcumin-containing food supplements (curcumin, turmeric and curry) or foods (curcumin, turmeric, E100, and curry) defined as at least 3 times per week and for 2 weeks prior to testing * Currently taking (and during the past 3 months) any prebiotics or probiotics supplementation from food or from dietary supplements * With significant change in food habits or in physical activity in the 3 months before the V0 visit or not agreeing to keep them unchanged throughout the study, * Trying to lose weight with a current or planned in the next 3 months specific diet (hyper or hypocaloric, vegan, vegetarian…) or exercice regimen * With a personal history of anorexia nervosa, bulimia or significant eating disorders according to the investigator, * Consuming more than 3 standard drinks of alcoholic beverage daily for men or 2 daily for women or not agreeing to keep his alcohol consumption habits unchanged throughout the study, * Having a lifestyle deemed incompatible with the study according to the investigator including high level physical activity (defined as more than 10 hours of significant physical activity a week, walking excluded), * Taking part in another clinical trial or being in the exclusion period of a previous clinical trial, * Having received, during the last 12 months, indemnities for clinical trial higher or equal to 4500 Euros, * Under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision, * Presenting a psychological or linguistic incapability to sign the informed consent, * Impossible to contact in case of emergency. After V0 biological analyses the subject will be considered as non-eligible to the study on the following criteria: \- Control record (Glycaemia, GGT, ASAT, ALAT, Urea, Creatinine and Complete blood count) with clinically significant abnormality according to the investigator