The study has been conducted to measure the clinical outcome of early intervention with colistin inhalation in patients with ventilator associated pneumonia suspected to have multidrug resistant gram -ve bacteria
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
Polymyxins are bactericidal drugs that bind to lipopolysaccharides (LPS) and phospholipids in the outer cell membrane of gram-negative bacteria.
Dual antipseudomonal given as IV for ventilator associated pneumonia for patients with Multi-drug resistant bacteria risk factors
Assessment of Ventilatory status
Pf ratio measurement
Time frame: 7 to 10 days
Days of mechanical ventilation
Deescalation in the ventilation mode and trials until successful weaning.
Time frame: 35 Days
Time till the occurence of sepsis
long standing ventilator associated pneumonia with failure of treatment can lead to sepsis
Time frame: 35 Days
Mortality as an outcome of long stand untreatable ventilator associated pneumonia
is the mortality due to sepsis of other causes
Time frame: 35 days
Length of stay in the icu
How long will the patient stay in the ICU according to failure of weaning and progression of the disease.
Time frame: 35 days
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