Evaluation of hypnosis therapy efficacy in addition to pharmacologic standard treatment of Croh disease during remission by the evaluation of quality of life;
Crohn disease is defined as an inflammatory chronic disease of the bowel characterize by intermittent flare-ups and remission periods. Crohn disease is due to genetic and environmental factors such as stress. Stress is an important aggravation factor of the disease symptoms which can stop a remission period and induce a relapse into a flare-up period. Hypnosis is a non-medicinal technic which already show efficacy in the treatment of functional digestive troubles. These diseases are bio/psycho/social models such as Crohn disease. Hypnosis can reduce visceral pain sensibility, reduce stress and reduce pro-inflammatory cytokines liberation into intestinal mucosa. Though, only few data are available on hypnosis interest in the treatment of Crohn disease and inflammatory bowel diseases as it is often isolated clinical case report. One study on patients with rectocolitis in remission period has been done recently and show that hypnosis increased the duration of the remission period. The principal objective of this study is to evaluate hypnosis efficacy in term of quality of life for patients with Crohn disease during remission.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
40
Standard Treatment : immunosuppressor/TNFalpha as in standard practice
8 hypnosis group sessions during 2 months
University Hospital
Grenoble, France
RECRUITINGMid term hypnosis efficacy with IBDQ
Efficacy evaluation of hypnosis 6 months after the beginning of hypnosis sessions on the quality of life with Inflammatory Bowel Disease Questionnaire (IBDQ)
Time frame: 6 months
Short term hypnosis efficacy with IBDQ
Efficacy evaluation of hypnosis 3 months after the beginning of hypnosis sessions on the quality of life with Inflammatory Bowel Disease Questionnaire (IBDQ)
Time frame: 3 months
Disease acceptance with ICQ-18
Impact of hypnosis on the disease acceptance short and mid term with the Evolution of the Illness Cognition Questionnaire for chronic disease
Time frame: 3 months and 6 months
Clinical score with Harvey-Bradshaw Index short and mid term
Evolution of the clinical score short and mid term with Harvey-Bradshaw Index
Time frame: 3 months and 6 months
Vagal tonus with electrocardiogram
Evolution of the vagal tonus with electrocardiogram short and mid term
Time frame: 3 months and 6 months
Inflammatory status with C Reactive Protein
Evolution of the C Reactive Protein concentration in the plasma
Time frame: 3 months and 6 months
Stress with Perceived Stress Scale
Evolution of stress status short and mid term with Perceived Stress Scale which goes from 10 to 50. Lower values represent better outcome.
Time frame: 3 months and 6 months
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Fatigue with Multidimensional Fatigue Inventory
Evolution of fatigue status short and mid term
Time frame: 3 months and 6 months
Long term hypnosis efficacy
Efficacy evaluation of hypnosis 12 months after the beginning of hypnosis sessions on the quality of life with Inflammatory Bowel Disease Questionnaire (IBDQ) which goes from 32 to 224. Higher values represent better outcome.
Time frame: 12 months
Clinical score with Harvey-Bradshaw Index long term
Evolution of the clinical score long term with Harvey-Bradshaw Index
Time frame: 12 months