Measuring Erythrocyte Iron Incorporation From Different Dosing Regimens in Anemic Women

Swiss Federal Institute of Technology20 enrolled

Overview

Iron-deficient anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice, absorption is low and compliance is poor due to mild gastrointestinal side effects. The investigators will compare iron absorption from labeled oral iron doses of 100mg and 200mg administered either on two consecutive days or on alternate days in young anemic women.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Iron Deficiency Anemia

Interventions

Iron stable isotope labeled iron(II) sulfateOTHER

Administration of oral stable isotope labels using different dosings and different regimens in women with iron deficiency anemia

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ferritin \<15 µg/L * Hb 8-11.9 g/dl * BMI 18.5-24.9 kg/m2 * Body weight \<70 kg Exclusion Criteria: * Severe anemia (Hb \<8 g/dl) * Elevated CRP \>5.0 mg/L * Chronic disease * Long-term medication, except contraception * Consumption of Mineral and Vitamin supplements within the study period * Therapeutic iron infusion over the past 6 months * Pregnancy or breastfeeding * Smoking

Locations (1)

Human Nutrition Laboratory ETH Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Fractional and total iron absorption

Fractional and total iron absorption from different supplementation regimens

Time frame: absorption will be measured 14days after the 100mg and 200mg cycle

Serum hepcidin

Serum hepcidin after the administration of different doses and using different regimens