Investigation of the iStent Inject® Devices in Open-Angle Glaucoma

Inclusion Criteria: * Primary open-angle glaucoma, pseudoexfoliative glaucoma, or pigmentary glaucoma * Mild to moderate glaucoma (defined as C/D ratio ≤ 0.8) * Phakic eye requiring cataract surgery * Preoperative IOP up to 30 mmHg (medicated or not) * Patients with side-effects to, or complications from, medications * Patients who would benefit from a reduction of IOP and/or reduction of medication * Normal angle anatomy as determined by gonioscopy; * Absence of peripheral anterior synechiae (PAS), rubeosis or other angle abnormalities that could impair proper placement of iStent inject device * Able and willing to attend scheduled follow-up exams for 12 months postoperatively * Able and willing to provide written informed consent on the approved Informed Consent Form Exclusion Criteria: * Inclusion of the fellow eye in this study (only one eye per subject) * Aphakic patients or pseudophakic patients * Prior stent implantations in the study eye * Eyes with primary angle closure glaucoma, or any secondary angle closure glaucoma * Traumatic or uveitic glaucoma; or any glaucoma associated with vascular disorders * Patients with any type of condition that may cause elevated episcleral venous pressure * Functionally significant visual field loss, including severe nerve fiber bundle defects such as Bjerrum scotoma * Prior glaucoma treatment (laser or surgery) * Any active corneal inflammation, edema, or opacity severe-enough to impair gonioscopy / fundus examination * Any pathology for which, in the investigator's judgment, the following would be either at risk or contraindicated: * stent implantation, * compliance to elements of the study protocol.