The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal.
1. Objective: To observe the difference between Thyogen® injection or Eltroxin® withdrawal on metabolic profile. 2. Background and method:: The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal. Inclusion : Patient number: 500人 Inclusion criteria : 1. Patients with diagnosis of thyroid cancer。 2. Patients who need radioiodine therapy or scan。 Exclusion criteria: 1. Patients cannot cooperate with blood test.。 2. Patients cannot cooperate with radioiodine therapy。 Study design: Prospective, observational study。 Method: We will collect 20cc blood and 20 cc urine before and after radioiodine therapy during each visit (total 3 visits) and check lipid profiles, glucose profiles and inflammation markers. We will compare the difference between results of patients undergoing Thyrogen® injection and Eltroxin® withdrawal.
Study Type
OBSERVATIONAL
Enrollment
300
Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan.
Division of Endocrinology and Metabolism in Taichung Veterans General Hospital
Taichung, Taiwan
Zung's Self-reported depression scale
Depression symtpoms
Time frame: 1 month
Brain-derived neurotrophic factor
BDNF
Time frame: 1 month
orexin
An associated factor for depression
Time frame: 1 month
Body composition
Fat component percentage to lean mass percentage ratio
Time frame: 1 months
VCAM-1
adhesion molecules
Time frame: 1 months
CRP
inflammation marker
Time frame: 1 months
Metabolic syndrome
The number of conponents for metabolic syndrome
Time frame: 1 months
Insulin resistance
HOMA-IR
Time frame: 1 month
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