Inpatient Challenge Study of rRSV A/Maryland/001/11, a Human Respiratory Syncytial Virus Challenge Strain, Administered to Healthy Adult Volunteers

Inclusion Criteria: * Non-pregnant adults between 18 years and 50 years of age, inclusive. * General good health, without significant medical illness, physical examination findings, or significant laboratory abnormalities as determined by the investigator. * Demonstrates comprehension of the protocol procedures and knowledge of RSV illness by passing a written comprehension examination (pass grade greater than or equal to 70%). * Available for the duration of the trial. * Willingness to participate in the study and stay confined to the inpatient unit for the required duration as evidenced by signing the informed consent document. * Participants with childbearing potential must agree to have used effective birth control methods beginning at least one month prior to challenge, and continuing with 'per label/fully effective use' for the chosen method for the duration of the study, from amongst these: * pharmacologic/hormonal contraceptives, including oral, parenteral, subcutaneous, and transcutaneous delivery; * condoms or diaphragm with spermicide; * intrauterine device; * absolute abstinence from heterosexual intercourse as a matter of normal preferred lifestyle; * or must be surgically sterile, or must be 50 years of age AND have had no menses at all for at least one full year. * All participants of childbearing potential must provide samples for urine and serum pregnancy testing prior to enrollment, prior to challenge, as well as a statement of menstrual history, at each study contact throughout the study, and report if they may be pregnant immediately. * Willingness to refrain from blood and plasma donation for 1 year after study enrollment. * Willingness to refrain from receiving licensed or investigational vaccines or other investigational products from the day of enrollment until Study Day 56. * Willingness to follow admission and isolation requirements for the indicated duration per protocol. Exclusion Criteria: * Subject who was previously challenged with RSV in any study, or previously participated in an RSV vaccine study. * Any subject who is pregnant or lactating OR planning to become pregnant in the timeframe that begins 30 days prior to the inoculation and ends 30 days after inoculation. Pregnancy is determined by a positive test for human chorionic gonadotropin (β-HCG test). * Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease by history, physical examination, and/or laboratory studies. * Behavioral or cognitive impairment or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol. * A history of asthma within the past 5 years, or a current diagnosis of asthma or reactive airway disease associated with exercise, seasonal hay fever or allergic rhinitis. * Presence of any febrile illness or symptoms suggestive of a respiratory infection within 2 weeks prior to inoculation. * Use of systemic or nasal steroid preparations or immunosuppressive drugs within 30 days prior to challenge. Topical steroid preparations are permitted. * Inhaled bronchodilator or inhaled steroid use within the last year or use after upper respiratory tract infections within the last 5 years. * Current or past (in the last 4 weeks) use of i.n. medications (including steroids, decongestants, or hormonal medications), or planning to use them within 28 days of study challenge * Positive urine drug toxicology test for the presence of amphetamine, barbiturates, opiates, phencyclidine, benzodiazepines, methadone or cocaine metabolites. * Evidence of current alcohol or illicit drug abuse or addiction. * Other condition that in the opinion of the investigator would jeopardize the safety or rights of a subject participating in the trial or would render the subject unable to comply with the protocol. * History of anaphylaxis. * Positive enzyme-linked immunosorbent assay (ELISA) and confirmatory tests for human immunodeficiency virus (HIV). * Positive ELISA and confirmatory test (e.g., recombinant immunoblot assay) for hepatitis C virus (HCV). * Positive hepatitis B virus surface antigen (HBsAg) by ELISA. * Known immunodeficiency syndrome. * Receipt of a live vaccine within 4 weeks or a killed vaccine within 2 weeks prior to inoculation with RSV challenge and planned receipt within 56 days after challenge. * History of surgical splenectomy. * Receipt of blood or blood-derived products (including immunoglobulin \[Ig\]) within 6 months prior to study inoculation. * Current routine (at least once weekly) smoking or vaping of a tobacco product or marijuana. * The decision to exclude a potential subject is determined by medical history and a clinician's clinical judgment based on the physical examination. * Receipt of any investigational vaccine or drug within 28 days prior or planned use within 56 days after study inoculation. * Body mass index (BMI) less than 18.5 or greater than 37.5. * Shared household, works closely with, or has routine contact with a child (children) less than 2 years of age or with immunocompromised individual(s), adults with significant cardiopulmonary disease, persons with significant asthma, institutionalized elderly or elderly with functional disability or any other individual that, in the judgment of the Principal Investigator (PI), might be at increased risk for complications if exposed to RSV. * Any significant abnormality of the nose or nasopharynx, including recurrent epistaxis and including nasal or sinus surgery. * History of Bell's palsy. * Unwillingness to have nasopharyngeal (NP) swabs, nasal wash, or blood samples saved for future respiratory virus research. * Serum RSV neutralizing antibody titers greater than or equal to 320.