The Canadian Armed Forces PEER Study

Inclusion Criteria: 1. Male and female subjects between the ages of 18 - 65 years of age who speak and read English. 2. Participants able to provide written informed consent to participate in the study. 3. Participants with a primary diagnosis of a DSM-V depressive disorder, including subjects with comorbidity of a non-psychotic behavioral disorder. 4. Participants with comorbidity of mild traumatic brain injury (mTBI) are eligible for inclusion in this study. mTBI will be defined according to best clinical practice guidelines. The subject should have experienced no more than 30 minutes of loss of consciousness, less than a 24 hour alteration in consciousness or mental status, less than 24 hours of post-traumatic amnesia and a Glasgow Coma Scale (best available score in the first 24 hours) of 13 or greater. 5. Participants with comorbidity of post-traumatic stress disorder (PTSD) are eligible for inclusion in this study. A score of 45 or greater on the PTSD Checklist Military/Civilian (PCL-M/C) measurement tool will qualify a subject for inclusion of diagnosis of PTSD as a comorbid condition. 6. Able to stop specified medications, including drugs of abuse, for 5 half-lives of the medication(s). See Appendix B for a list of the five half-life time periods for these medications. • The potential subject's primary care physician may be consulted to make these determinations. 7. Able to be washed out of specified medications within 14 days, i.e. 5 half-lives are not longer than 14 days (See Appendix B). 8. Participants will be selected from patients on the psychiatric inpatient ward, partially hospitalized patients, and psychiatric outpatients. 9. Ability to comply with the requirements of the study. Exclusion Criteria: 1. Male and female subject less than 18 years old or greater than 65 years old 2. Participants who cannot provide written informed consent 3. Diagnosis of a psychotic disorder. 4. History of, or current, open head brain trauma. 5. Subjects with comorbidity of mild traumatic brain injury (mTBI) or traumatic brain injury (TBI) who experienced greater than 30 minutes loss of consciousness, greater than 24 hour alteration in consciousness or mental status, greater than 24 hours of post traumatic amnesia, or a Glasgow Coma Scale (best available score in first 24 hours) of less than 13. 6. Subjects who, in the opinion of the investigator, are unable to washout of specified medications in a period of 14 days or less.. 7. History of: craniotomy, cerebral metastases, cerebrovascular accident; current diagnosis of seizure disorder, schizophrenia, schizo-affective disorder, dementia, mental retardation, or major depression with psychotic features; or use of depot neuroleptics in last 12 months. 8. Clinically significant medical illness, including thyroid disorders, which cannot be remediated with medication, e.g. synthroid. 9. Participation in any other therapeutic drug study within 60 days preceding inclusion. 10. Known pregnancy and/or lactation, or intent to become pregnant during this study. 11. Chronic or acute pain requiring prescription pain medication(s) (narcotic or synthetic narcotic). 12. Candidates with any metal, shrapnel or other similar objects in the head that could affect the QEEG. 13. Candidates currently stable and considered to be at Maximum Medical Improvement (MMI) on current medications. 14. Participant has a positive urine drug screen. 15. Participant has active suicidal intent.