Rôle of the Soluble Endothelial Protein C Receptor in Cirrhosis-associated Hypercoagulability State (EXERCISE)

Patients with cirrhosis Inclusion criteria : * Male, age 18 or older * Cirrhosis, defined by: prothombin time ≤ 70% +/- liver dysmorphism +/- Fibroscan \> 12.5 kPa +/- histology +/- portal hypertension associated with hepatocellular insufficiency * Cirrhosis associated with hepatitis B or C, or alcoholic liver disease, or non alcoholic steato hepatitis * Measurable portal flow by ultrasound doppler * Child Pugh score A,B or C, without acute infection or acute bleeding * Signed written informed consent * Affiliation to french social security system Exclusion criteria : * Known history of vein thrombosis * Known family history (in first-degree relative) of spontaneous thrombosis * Partial or complete portal system vein thrombosis * Uncontrolled infection after 7-day course of antibiotics * Anticoagulant intake * Hepatocellular carcinoma * Protected or deprived of liberty adult * Any medical or surgical history that could interfere with the study, as judged by the investigator * Blood transfusion within 7 days * Participation in a clinical trial for drug Healthy volunteers Inclusion criteria : * Male, age 18 or older * Body Mass Index between 18 and 30 kg/m2 * Normal physical examination * Willing and able to comply with requirements of the study * Agree to be registered in the french national registry for healthy volunteers * Signed written informed consent * Affiliation to french social security system Exclusion criteria : * Any medical or surgical history that could interfere with the study, as judged by the investigator * Participation in a clinical trial for drug * Protected or deprived of liberty adult * Known history of vein thrombosis * Known family history (in first-degree relative) of spontaneous thrombosis * Anticoagulant intake Patients with hepatocellular carcinoma (HCC) Inclusion criteria : * Male, age 18 or older * Histological diagnosis of HCC, or use of BCLC criteria for diagnosis * Treatment naïve HCC * Measurable portal flow by ultrasound doppler * For patients with cirrhosis: Child Pugh score A,B or C, without acute infection or acute bleeding * Signed written informed consent * Affiliation to french social security system Exclusion criteria : * Known history of vein thrombosis * Known family history (in first-degree relative) of spontaneous thrombosis * Partial or complete portal system vein thrombosis * For patients with cirrhosis: uncontrolled infection after 7-day course of antibiotics * Anticoagulant intake * Protected or deprived of liberty adult * Any medical or surgical history that could interfere with the study, as judged by the investigator * Blood transfusion within 7 days * Prior treated malignancy within the previous 2 years (except basal cell and squamous cell skin cancer, and superficial bladder cancer) * Participation in a clinical trial for drug