Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in France. The consequences in terms of morbidity and perinatal morbidity and the medical and economic costs make it an issue public health. Pre-eclampsia associates maternal hypertension with dysfunction kidney. There is no cure for pre-eclampsia or IUGR vascular during pregnancy. These pathologies invariably evolve towards a maternal and / or fetal aggravation sometimes very fast. Primary prevention and secondary education and screening for these pathologies are still insufficient. A better understanding of the pathophysiology of these placental vascular pathologies is necessary for the development of supported medical, obstetric and pediatric that will improve the state of health maternal and neonatal
Study Type
OBSERVATIONAL
Enrollment
500
collect of placenta, blood and urinary samples at delivery
CHi Creteil
Créteil, France
RECRUITINGgenomic analysis on placenta
by chromatin immunoprecipitation-sequencing (ChIP-seq)
Time frame: day of delivery
genomic analysis on blood
by ChIP-seq
Time frame: day of delivery
genomic analysis on placenta
by immunohistochemistry an polymerase chain-reaction
Time frame: day of delivery
VEGF blood level
Time frame: day of delivery
PLGF blood level
Time frame: day of delivery
sFlt1 blood level
Time frame: day of delivery
sKDR blood level
Time frame: day of delivery
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