Effects of Menthol on Dyspnoea in COPD Patients

Groupe Hospitalier du Havre63 enrolled

Overview

Chronic obstructive pulmonary disease (COPD) is characterised by non-reversible bronchial obstruction associated with systemic disorders and comorbid factors. Dyspnoea is a common symptom among patients with Chronic Obstructive pulmonary Disease (COPD). Dyspnea is the primary symptom limiting exercise and daily activities in these patients. It has been reported that breathing cold air could decrease dyspnoea induced by exercise and could improve exercise performance. The aim of this study is to carry out the effect of cooling sensation induced by menthol chewing-gum on dyspnoea and exercise performance among patients with COPD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Copd Dyspnea Lung Diseases

Interventions

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * a diagnosis of COPD * Dyspnea in daily living (2-4 on the modified medical research council dyspnea scale) * Clinically stable Exclusion Criteria: * exercise contraindication Any musculoskeletal problems, cardiovascular or neurological comorbidities that limits exercise. * exacerbation during the study * Inability to chew or patients with swallowing disorders

Locations (3)

Centre hospitalier des Pays de Morlaix

Morlaix, Brittany Region, France

Resp'Air

Talence, New Aquitaine, France

Groupe Hospitalier du Havre

Le Havre, Normandy, France

Outcomes

Primary Outcomes

Change in Dyspnea after each tests

Change in dyspnea using Modified Borg Scale (0 - 10 points) 0=no dyspnea ; 10 = maximal effort

Time frame: The outcome will be measured before and at the end of the test, the two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.

Secondary Outcomes

Change in respiratory rate

Change in respiratory rate (cycles per minute) will be measured breath-by-breath using a Respiratory Inductive Plethysmography

Time frame: Data will be continuously collected during every tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.

Change in inspiratory capacity

Change in inspiratory capacity (Liters) will be measured using a portable spirometer

Time frame: The outcome will be measured before and at the end of the test, the two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.

Change in Cardiac Frequency

Change in Cardiac Frequence (bpm) using a pulse oximetry

Time frame: Data will be continuously collected during every tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.

Change in Oxygen Saturation

Change in Oxygen Saturation (%) using a pulse oximetry

Time frame: Data will be continuously collected during every tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.

Change in tidal volume

Change in tidal volume (Liters) will be measured breath-by-breath using a portable spirometer

Time frame: The outcome will be measured before and at the end of the test, the two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.

Change in 6-min walk distance

Change in 6-min walk distance (meters).

Time frame: The outcome will be measured at the end of each tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day.