Muscle Tenderness and Hardness in Migraine Patients

Danish Headache Center146 enrolled

Overview

The aim of the study is to examine symptomatology, quantitative sensory test (QST) parameters, muscle tenderness and muscle hardness in migraine patients interictally and compare with healthy controls

Migraine patients exhibit different symptomatology and responses to treatment. For example do many migraine patients have neck symptoms, despite they apparently do not have any neck disorders.Furthermore the response to treatment differs between patients. Differences in symptomatology, QST parameters and muscle stiffness can be used to subdivide and phenotype migraine patients. The investigators are examining migraine patients with: A semistructured interview, Quantitative sensory testing (cold pain threshold, heat pain threshold and Pin Prick), Muscle tenderness (total tenderness score, local tenderness score and stimulus response curve), and muscle hardness with ultrasound elastography. All tests are performed the same day

Study Type

OBSERVATIONAL

Enrollment

146

Conditions

Migraine Disorders Muscle Tenderness Headache Disorders, Primary Nervous System Diseases Headache, Migraine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Migraine Patients from the Danish Headache Centre. Migraine classified using the International Classification of Headache Disorders (ICHD3) criteria. Exclusion Criteria: * Pregnant or lactating women * Musculoskeletal injuries in the neck or shoulder * Other primary headache disorders than migraine or Tension Type Headache * On the time of examination: Migraine free for at least 48 hours * On the time of examination: haven't trained the upper body for at least 48 hours * On the time of examination: haven't used painkillers for at least 48 hours Healthy controls: Exclusion Criteria: * Pregnant or lactating women * Musculoskeletal injuries in the neck or shoulder * Migraine disorders * 1\. degree relatives with migraine disorders * Over 1 day of tension type headache a month. * On the time of examination: haven't trained the upper body for at least 48 hours * On the time of examination: haven't used painkillers for at least 48 hours

Locations (1)

Danish Headache Center

Glostrup Municipality, Denmark

Outcomes

Primary Outcomes

Logistic regression model, Neck Stiffness

We would like to examine the relationship between the variable variable: Neck stiffness during migraine attack (Yes/No) and the Independent variables: Total Tenderness Score (summed score from 8 points bilateral, each point can score 0-3), Migraine localisation (occipital: Yes/No), Tension Type Headache, Allodynia (yes/No), Stimulus response curve (Pressure and Pain). The result shows how much of the variability in neck stiffness that can be explained by the independent variables.

Time frame: 3 hours

Pericranial Muscle Tenderness

We will examine whether patients with neck stiffness during migraine attack (yes/no) have higher tenderness scores compared to patients without neck stiffness during migraine attacks, when correcting for headache frequency.

Time frame: 3 hours

Muscle Hardness measured by ultrasound elastography

Muscle hardness (m/s) in migraine patients compared to healthy controls.corrected for age, BMI and sex

Time frame: 3 hours

Muscle hardness measured by ultrasound elastography in migaine patients

Muscle hardness (m/s) in migraine patients with neck stiffness during migraine attacks compared to migraine patients without neck stiffness during migraine attacks. Corrected for age, BMI and sex.

Time frame: 3 hours

Secondary Outcomes

Multiple Regression model, Total Tenderness Score

We would like to examine the relationship between the dependent variable: Total Tenderness Score(summed score from 8 points bilateral, each point can score 0-3), and the Independent variables: Neck Pain in general(Yes/No), Migraine localisation (occipital: Yes/No), Headache Frequency(days/month), Allodynia (Yes/No), Years with Migraine(Number of years)

Time frame: 3 hours

Data from ClinicalTrials.gov

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