Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis

The Hong Kong Polytechnic University40 enrolled

Overview

Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Osteoarthritis, Knee

Interventions

ExerciseOTHER

Comprehensive exercise program including strengthening, stretching, gait modification etc.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 50-80 2. having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3 3. having medial knee pain on most days of the month 4. having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking Exclusion Criteria: 1. having lateral tibiofemoral compartment osteophytes greater than the medial side. 2. having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months 3. having a systemic arthritic condition (e.g., rheumatoid arthritis) 4. having a knee joint replacement or high tibial osteotomy in the past 5. having any other muscular, joint or neurological condition influencing lower limb function 6. unable to walk unaided 7. having low back, hip, ankle or foot pain \> 3 on numerical rating scale 8. having a body mass index (BMI) \>36 kg/ m2

Locations (1)

Queen Mary Hospital

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System

External knee moment in the frontal plane during early stance phase of walking

Time frame: At baseline and one week after intervention

Secondary Outcomes

Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score

Pain intensity measured by the pain subscale of Knee injury and Osteoarthritis Outcome Score (KOOS). The minimum value is 0 and maximum value is 100. The higher scores mean a better outcome.

Time frame: At baseline and one week after intervention

Tibial Torsion as Assessed by X-ray Imaging

The angle between tibial and femur in the transverse plane

Time frame: At baseline

Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography

Young's modulus by ultrasound elastography

Time frame: At baseline and one week after intervention

Data from ClinicalTrials.gov

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