Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.
NEPTUN consists of liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and/or biopsy criteria.
Study Type
OBSERVATIONAL
Enrollment
747
University Hospital Bonn
Bonn, Germany
Survival
death, liver transplantation
Time frame: up to 10 years
Ascites
Evaluation of amount of ascites according to the Child-Score
Time frame: up to 10 years
Hepatic Encephalopathy
Evaluation of the grade according to the West Haven Criteria
Time frame: up to 10 years
Variceal Bleeding
Assessment of presence of variceal bleeding
Time frame: up to 10 years
Liver Failure
defined as Bilirubin level ≥ 12mg/dl
Time frame: up to 10 years
Acute-on-Chronic-Liver Failure (ACLF)
Presence of ACLF according to the EASL-Chronic liver Failure Consortium (CLIF)-criteria
Time frame: up to 10 years
Organ Failures
Assessment of Organ failures according to the CLIF-SOFA according to CLIF-Sequential Organ Failure Assessment (SOFA) Score
Time frame: up to 10 years
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