BIOLOGICAL EXPLORATION OF THE VASCULAR FRACTION FROM THE ADIPOSE TISSUE OF PATIENTS WITH SCLERODERMIA

Inclusion Criteria: Patients with systemic scleroderma: * fulfilling the inclusion criteria for the SCLERADEC 2 trial: patients with systemic Scleroderma older than 18, desiring a therapeutic alternative and having a functional impotence authenticated by a functional index of Cochin's hand greater than 20. * having given their consent for the constitution of a sample in the biological collection * having completed the follow-up visit to M3 of the SCLERADEC 2 study to have responder / non-responder status. Healthy volunteers: * having recourse to a liposuction operation for aesthetic reasons, * with a BMI between 18 and 27, * not declaring chronic diseases, * having signed the non-opposition Exclusion Criteria: Patients with systemic scleroderma: * Body mass index (weight-to-height ratio squared) less than 18 * Major Sclerodactyly objectified by Rodnan score applied by hand\> 16 (out of a total of 18 points) * Severe tendon retraction of the fingers objectified by a defect extension in passive measure in goniometry\> 90 ° C for at least 2 proximal interphalangeal joints * Digital infection (including infected ulcer, ulcer with local inflammatory signs and clinical suspicion of osteitis) * Pulmonary arterial hypertension and / or progressive and / or oxygen-dependent pulmonary fibrosis * Prescription of a new systemic treatment for Systemic Scleroderma in the month prior to inclusion * Persons infected with HIV, HCV, HBV, HTLV and syphilis * Patients on immunosuppressants outside corticosteroid therapy \<10 mg / day and methotrexate * Known hypersensitivity to human albumin For healthy patients and volunteers: * Contraindication to surgery (patients on anticoagulant or antiaggregant, disorders of haemostasis, contraindication to the analgesic protocol used) * Premenopausal women of childbearing age without contraception * Minors * Pregnant or lactating women * Majors protected by law (under tutorship or curatorship) * Persons staying in a health or social facility * People in emergency * Persons deprived of their liberty * Inmates * Non-beneficiaries of a social security scheme * Absence or refusal of non-opposition