PRP Prevents Recurrence of Intrauterine Adhesions

Yanhong Deng60 enrolled

Overview

Effect of platelet-rich plasma (PRP) on uterine scar fibrosis, endometrial receptivity and pregnancy outcome in patients with severe intrauterine adhesions

1. Inclusion criteria: patients with intrauterine adhesions (AFS score \>9 points); age 21 to 40 years old, with fertility requirements. 2. Study design:prospective, randomized controlled cohort study, patients with intrauterine adhesions were randomized into two groups, the control group and the intervention group (intraoperative and postoperative 1 week postoperative PRP). The surgical procedures and postoperative medication regimens were the same. 3. Compare the biochemical pregnancy rate, clinical pregnancy rate, abortion rate and live birth rate after hysteroscopic resection in PRP group and control group, and explore the effect of PRP on pregnancy outcome after intrauterine adhesion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Intrauterine Adhesion

Interventions

Platelet-rich plasmaPROCEDURE

Platelet-rich plasma intrauterine injection

gelPROCEDURE

Self-crosslinking sodium hyaluronate gel intrauterine injection

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 37 Years

Medical Language ↔ Plain English

Inclusion Criteria:Patients with intrauterine adhesions (AFS score \>9 points); age 21 to 40 years old, with fertility requirements - Exclusion Criteria:Endometrial tuberculosis, endometrial polyps, uterine submucosal fibroids, endometrial hyperplasia, endometrial malignant lesions, premature ovarian failure, chromosomal abnormalities \-

Outcomes

Primary Outcomes

AFS score

Time frame: 1 year

Data from ClinicalTrials.gov

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