Diagnosis of MGRS in Patients With Paraproteinemias: Clinical, Anatomopathological and Pathophysiological Study

Academia Nacional de Medicina15 enrolled

Overview

This is the first prospective study which evaluate patients with small B-cell clones to diagnose monoclonal gammopathy of renal significance (MGRS) and characterize it clinically, anatomopathologically and pathophysiologically taking int account a geriatric approach.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Monoclonal Gammopathy of Renal Significance

Eligibility

Sex: ALLMin age: 18 YearsMax age: 89 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Paraproteinemias Exclusion Criteria: * Multiple Myeloma * Waldenstrom Macroglobulinemia * Chronic Lymphocytic Leukemia * Malignant Lymphoma * Monoclonal gammopathy of unknown significance (MGUS) secondary to Infections * MGUS secondary to Autoimmune Diseases * Uncompleted hematological evaluation * Renal tumor except for cysts Bosniak type I/II * Other malignant neoplasia * Unresolved obstructive uropathy * Patients with only one kidney except for renal transplant * Co-morbidities which would limit the ability to receive aggressive therapeutic intervention * Fragile old people * Pregnancy * Prison * Impatient in psychiatric institutions.

Locations (1)

Academia Nacional de Medicina

Buenos Aires, Argentina

RECRUITING

Outcomes

Primary Outcomes

Renal histopathology compatible with MGRS

Time frame: through study completion, an average of 1 year

Secondary Outcomes

Renal physiopathological changes

Time frame: through study completion, an average of 1 year

Central Contacts

Mariana Ciocchini, Nephrologist

CONTACT

+54 9 11 6172 2738 marianaciocchini@pm.me

Data from ClinicalTrials.gov

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