Mechanical Ventilation During Cardiopulmonary Bypass

Azienda Ospedaliera di Padova80 enrolled

Overview

The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Congenital Heart Disease Mechanical Ventilation Complication Cardiopulmonary Bypass

Interventions

Ventilation during cardiopulmonary bypassPROCEDURE

Mechanical ventilation during cardiopulmonary bypass

Eligibility

Sex: ALLMax age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * congenital heart diseases * younger than 5 years * CPB longer than 30 minutes in hypotermia * elective surgery * stable clinical conditions Exclusion Criteria: * genetic anomalies * mechanical ventilation before the surgery * kidney injuries * hepatic failure

Locations (1)

AOPadova

Padua, Italy

Outcomes

Primary Outcomes

Evaluation of the damage of the air-blood membrane in a ventilation protocol and a non ventilation protocol during cardiopulmonary bypass

It will be assed the plasma level of proteins which usually are absent in the plasma (surfactant protein A and B) that change as a damage of the air-blood membrane appears.

Time frame: Baseline, and 6, 12, 24 and 48 hours after the surgery

Data from ClinicalTrials.gov

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