Relationship Between Blood Glucose Variability and Prognosis in Critically Ill Patients

Nanjing First Hospital, Nanjing Medical University200 enrolled

Overview

This study is to evaluate the glycemic variation using Continuous Glucose Monitoring System in patients in the intensive care unit, find out the occult hypoglycemia, and investigate the relationship between glycemic variation, especially the incidence of hypoglycemia and prognosis of patients. Meanwhile, the inflammatory factors were measured and the relationship between inflammatory factors and glycemic variation.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Diabetes

Interventions

Continuous Glucose Monitoring SystemDIAGNOSTIC_TEST

Continuous Glucose Monitoring System for 72 hours

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with history of diabetes; 2. Patients without history of diabetes, but their random blood glucose≧7.8mmol/L or fast blood glucose≧5 mmol/L; 3. The patients hospitalized in care unit (ICU or CCU) for more than 48 hours. Exclusion Criteria: 1. Patient had history of mental illness; 2. Patient was not suitable for using the CGMS; 3. blood glucose \> 22.2 mmol/L at admission.

Outcomes

Primary Outcomes

28 day prognosis

Case-fatality at 28 days

Time frame: 0-28 days

Secondary Outcomes

Acute Physiology and Chronic Health Evaluation II score

Time frame: 0-28 days

Global registry of acute coronary events risk score

Time frame: 0-28 days

Twenty-four-hour mean blood glucose

Twenty-four-hour mean blood glucose assessed by CGM

Time frame: 1-4 days

Mean amplitude of glycemic excursion every 24 h

Mean amplitude of glycemic excursion every 24 h assessed by CGM

Time frame: 1-4 days

Incidence of hypoglycemia

Time frame: 1-4 days

Central Contacts

Huiqin Li, MD

CONTACT

+8625-5288-7090 lihuiqin496@126.com

Data from ClinicalTrials.gov

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