Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality

University Hospital Southampton NHS Foundation Trust1,500 enrolled

Overview

The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin. With advancing technology this test has become more sensitive and is now called a high sensitivity troponin. This is a very effective way of rapidly excluding a heart attack if the test is negative. However there are a number of causes of a raised high sensitivity other than a heart attack, particularly critical illness states. In the absence of features of a heart attack an abnormal result therefore suggests that the heart is inflamed or unwell causing the release of high sensitivity troponin. The DIGNITY study will examine the consequences of high sensitivity troponin elevation in patients in intensive care and assess whether it has a role as a biomarker for predicting outcome.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Myocardial Infarction Myocardial Injury

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (aged 18 years or older) admitted to any of the three intensive care facilities on site (general, cardiac and neurosciences) * Biochemistry samples already taken as part of routine clinical care during the ICU stay Exclusion Criteria: * Patients aged less than 18 years * No biochemistry samples taken within the ICU stay

Locations (1)

Outcomes

Primary Outcomes

Association between high sensitivity troponin and inpatient mortality on all patients admitted to each of the ICU environments at a large teaching hospital

Time frame: During intensive care admission

Secondary Outcomes

Distribution of high sensitivity troponin results for different admissions to intensive care

Distribution of high sensitivity troponin results in * Medical admissions * Trauma / emergency surgical admissions * Planned surgical admissions * Post cardiac surgical patients * Neurosurgical patients

Time frame: During intensive care admission

Association between high sensitivity troponin results and duration of ventilation

Time frame: Within twenty eight days

Association between high sensitivity troponin results and length of intensive care admission

Time frame: Number of days not in intensive care within twenty eight days of original intensive care admission

Association between high sensitivity troponin results and requirement for inotropic support

Time frame: During intensive care admission

Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts