This human study will test the impact of dietary supplement vegicaps containing Korean Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and other germs and natural killer (NK) cells that kill virus-infected cells and cancers. The investigators had done an earlier study with Korean Angelica supplement and discovered even a single dose of it increased blood neutrophils and NK cells within 24 h. In the new study, Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo) capsules. This is to make sure the immune boosting actions are really from the Korean Angelica supplement.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
15
AGN
Placebo
Penn State College of Medicine
Hershey, Pennsylvania, United States
Neutrophil counts and NK cell counts in peripheral blood
Using CBC diff to measure neutrophil counts, NK cells number will be enumerated using flowcytometer
Time frame: 70 days
T cells in peripheral blood,
T cells number will be enumerated using flowcytometer
Time frame: 70 days
Plasma concentrations of pyranocoumarins, androgens, and inflammatory/anti-inflammatory cytokines.
Determine Plasma concentrations of pyranocoumarins (as compliance marker), androgens, and inflammatory/anti-inflammatory cytokines.
Time frame: 70 days
Lipid profiling
blood test will be done at every visit
Time frame: 70 days
NK mRNA signature
NK mRNA signature by RNA-seq transcriptomics using RNA prepared from Pax Gene tube-preserved whole blood collected on each visit
Time frame: 70 days
PBMC isolation for testing NK activity
PBMCs will be isolated at every blood draw and kept frozen. They will be used to determine NK cell activity in future.
Time frame: 70 days
CMP-EGFR
blood test will be done at every visit
Time frame: 70 days
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