Anti-VEGF intravitreal injections are the treatment of choice in age-related macular degeneration (AMD). However 37% of patients are unresponsive or poorly responsive to these therapies. It is still not possible to foresee the patient's response to anti-VEGF injections. A poor response may be related to an activation of alternative pro-angiogenic pathways with over expression of many other pro-angiogenic cytokines. The primary goal of this study is to measure the aqueous humor concentration of pro-angiogenic cytokines in AMD patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
100
In addition to the routine examinations performed as part of the usual care of AMD patients, an anterior chamber puncture will be performed to collect the aqueous humor samples.
Hôpital Pasteur 2 - Service d'Ophtalmologie
Nice, France
Change of pro-angiogenic cytokines concentration in the aqueous humor of patients with exudative AMD at 3 months
Time frame: At Month 3
Dose of VEGF in the aqueous humor of patients with exudative AMD
Time frame: At Day 0, Month 1, Month 2, Month 3
Dose of pro inflammatory cytokines in the aqueous humor of patients with exudative AMD
Time frame: At Day 0, Month 1, Month 2, Month 3
Measurement of visual acuity with Snellen chart
Time frame: At Day 0, Month 1, Month 2, Month 3
Measurement of visual acuity with ETDRS visual acuity chart
Time frame: At Day 0, Month 1, Month 2, Month 3
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