Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida

Joseph Bliss12 enrolled

Overview

This study evaluates whether adding a dietary supplement similar to coconut oil (MCT oil) to feedings in premature infants will reduce the amount of yeast (Candida) detectable in their stool. Infants who have Candida in their stool are eligible to participate. Half of the enrolled infants will have additional MCT oil added to their feedings and half will not.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Candida Infection Premature Infant

Interventions

Medium-Chain Triglyceride (MCT) OilDRUG

Infants receive 0.5 ml/oz of MCT oil to their prescribed feedings for 21 days or until hospital discharge.

Eligibility

Sex: ALLMax age: 6 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Premature infant admitted to the Neonatal Intensive Care Unit at Women \& Infants Hospital * Receiving full enteral feeds of either preterm or transitional formula or fortified breast milk * Anticipated to have a minimum stay of two weeks Exclusion Criteria: * Prior exposure to antifungal drugs

Locations (1)

Women & Infants Hospital of Rhode Island

Providence, Rhode Island, United States

Outcomes

Primary Outcomes

Stool Fungal Burden

Change in colony-forming units (cfu) of Candida per gram of stool. Data table reflects total number of stool samples collected from subjects in each group that were included in the analysis.

Time frame: Before supplementation, 1 week after supplementation begins, 3 weeks (at conclusion of supplementation)

Data from ClinicalTrials.gov

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