Sequential Versus Single O2 Levels on Human Embryo Development

Ibn Sina Hospital487 enrolled

Overview

Myriads of elements affect human embryo culture in vitro. These include, but not limited to, air quality, culture media, culture temperature, incubator humidity, pH, and O2 levels. O2 tension has been thoroughly investigated and, to date, 5% O2 level is superior to 20%. Reports showed that lowering the O2 from Day 3 of embryo culture seems to be physiological.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

487

Conditions

Embryo Culture

Interventions

Sequential O2 CultureOTHER

We investigate the effect of sequential O2 levels on human embryo culture after Intracytoplasmic sperm injection (ICSI)

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ICSI cycles undergoing their first ICSI attempt Exclusion Criteria: * ICSI cycles with a previous failure

Locations (3)

Qena Fertility Center

Qina, Qena Governorate, Egypt

Banon Assiut

Asyut, Egypt

IbnSina IVF Center

Sohag, Egypt

Outcomes

Primary Outcomes

Ongoing Implantation rate

number of sacs with a heartbeat after week twelve of gestation

Time frame: three months

Secondary Outcomes

clinical and ongoing pregnancies

registered pregnancy with fetal heartbeat at week four after transfer and after week twelve of gestation

Time frame: three months

human embryo development in vitro

Time frame: three months

Data from ClinicalTrials.gov

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