Imaging With a PET Agent for Detection of Cancers of the Head and Neck

Inclusion Criteria: Part 1: * Age ≥18 years * ECOG performance status 0 or 1 * Biopsy (histologically or cytologically) proven Squamos Cell Carcinoma * Oral cavity, oropharynx, or nasopharynx primary site * At least one tumor lesion on standard of care imaging with a minimum diameter of at least 1.5 cm * Scheduled to undergo treatment at MSKCC * Willingness to sign informed consent Part 2 * Age ≥18 years * ECOG performance status 0 or 1 * Biopsy (histologically or cytologically) proven Squamous Cell Carcinoma * Oral cavity,oropharynx, or nasopharynx primary site * Scheduled to undergo surgery (neck dissection and/ or neck dissection + surgical removal of the primary) at MSK * Willingness to sign informed consent * Should have had a standard-of-care \[18F\]-FDG PET/CT scan before surgery (to minimize the possibility of new alterations developing between the two scans both scans should be acquired within a maximum time difference of one month). Exclusion Criteria: * Significantly impaired organ function that may interfere with the excretion and metabolism of the imaging agent. Specifically, patients will be excluded if they meet the following criteria: * Hematologic o Platelets \<75K/mcL * Hepatic * Bilirubin \>2.0 x ULN (institutional upper limits of normal) * AST/ALT \>2.5 x ULN * Renal o Creatinine \> 2.0 x ULN * Claustrophobia interfering with PET/CT imaging * Known allergy to PEG300 * Pregnancy or breastfeeding