Gala Early Feasibility Study of RheOx

Inclusion Criteria: 1. Subject is diagnosed with chronic bronchitis for a minimum of two years, where chronic bronchitis is defined clinically as chronic productive cough for three months in each of two successive years in a patient in whom other causes of productive cough have been excluded. 2. Subject responds to the first two questions of the CAT must sum to at least 7 points. If the sum of the first two CAT questions is 6 points and the subject's total CAT score is greater than 20 points, the subject may be enrolled. 3. Subject has preprocedure post-bronchodilator FEV1 of greater than or equal to 30% and less than or equal to 80% of predicted within three months of enrollment. 4. Subject has had 1 or more COPD exacerbations, defined as an acute worsening in respiratory symptoms that requires additional treatment, in the 12-months prior to enrollment. 5. Subject has a SGRQ score of greater than or equal to 25 and CAT score of greater than or equal to 10. 6. Subject has a cigarette smoking history of at least ten packs years. 7. Subject in the opinion of the site investigator is able to adhere to and undergo two bronchoscopies and has provided a signed informed consent. Exclusion Criteria: 1. Subject has lower respiratory infection (e.g., common cold, pneumonia, MAI, tuberculosis) within the six weeks prior to the initial treatment bronchoscopy or mild or moderate COPD exacerbation (per GOLD guidelines) within 4 weeks of the procedure. 2. Subject is taking \> 10 mg of prednisolone or prednisone per day. 3. Subject has an implantable cardioverter defibrillator or pacemaker. 4. Subject has a history of cardiac arrhythmia within past two years. 5. Subject has history of unresolved lung cancer in last 5 years. 6. Subject has bullous disease as defined by bullae exceeding 3 cm in diameter on HRCT. 7. Subject has pulmonary nodule or cavity rthat in the judgement of the investigator may require intervention during the course of the study. 8. Subject has prior lung surgery, such as lung transplant, LVRS, lung implant/prosthesis, metal stent, valves, coils, bullectomy, segmentectomy, or lobectomy. Pneumothorax without lung resection is acceptable. Pleural procedures without surgery are acceptable. 9. Subject has clinically significant cardiomyopathy. 10. Subject has severe bronchiectasis as outlined in the report of the CT scan of the chest by the interpreting radiologist or in the view of the PI, those findings bronchiectasis or any other significant second lung disease, are the main drivers of the patient's clinical symptoms. 11. Subject actively smoked (including tobacco, marijuana, e-cigarettes, vaping, etc.) within the last 6 months. 12. Subject has the inability to walk over 100 meters in 6 minutes. 13. Subject has clinically significant serious medical conditions, such as: congestive heart failure, angina or myocardial infarction in the past year, renal failure, liver disease cerebrovascular accident within the past 6 months, uncontrolled diabetes, uncontrolled hypertension or autoimmune disease. 14. Subject has uncontrolled GERD. 15. Subject has sever pulmonary hypertension. 16. Subject has known sensitivity to medication required to perform bronchoscopy (such as lidocaine, atropine, and benzodiazepines). 17. Subject is pregnant, nursing, or planning to get pregnant during study duration. 18. Subject has received chemotherapy within the past 6 months or is expected to receive chemotherapy during participation in this study. 19. Subject is or has been in another clinical investigational study within 6 weeks of baseline. 20. Subject on anticoagulation for cardiovascular indications and is unable to have anticoagulants (i.e., Aspirin, Plavix, Coumadin) withheld for at least seven days prior to bronchoscopy in the opinion of the Investigator.