The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.
Study Type
OBSERVATIONAL
Enrollment
18
University of Maryland Medical Center
Baltimore, Maryland, United States
Influence of renal replacement therapy on drug exposure (AUC of plasma concentration levels)
Simultaneous samples will be taken from pre-filter, post-filter, and effluent sampling ports before dose administration, after the completion of the infusion or 1 hours post oral dose, and 6 additional time points post-infusion or post oral administration.
Time frame: Single Dosing Interval - 12 hours
Influence of renal replacement therapy on drug clearance
Simultaneous samples will be taken from pre-filter, post-filter, and effluent sampling ports before dose administration, after the completion of the infusion or 1 hours post oral dose, and 6 additional time points post-infusion or post oral administration.
Time frame: Single Dosing Interval - 12 hours
Determination of drug specific sieving coefficient (SC)
SC is a measure of a filter efficiency in clearing drugs and solute. SC will be calculated using pre-filter and effluent concentrations
Time frame: Single Dosing Interval - 12 hours
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Standard of care
Standard of care
Standard of care